α-Alkylidene δ-lactones inhibit quorum sensing phenotypes in<i>Chromobacterium</i>strain CV026 showing interaction with the CviR receptor-Reference-Cited by-同舟云学术

α-Alkylidene δ-lactones inhibit quorum sensing phenotypes inChromobacteriumstrain CV026 showing interaction with the CviR receptor

Published:2023 Issue:26 Volume:13 Page:18045-18057
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Favero Fernanda¹²,Tolentino Terezinha Alves¹,Fernandes Vinicius³,Treptow Werner³,Pereira Alex Leite²,Lira Machado Angelo Henrique¹^ORCID

Affiliation:

1. Instituto de Química, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910‐900, Brazil

2. Campus of Ceilândia, University of Brasília, Centro Metropolitano, Conjunto A, Ceilândia Sul, Brasília, DF, 72220-275, Brazil

3. Laboratório de Biologia Teórica e Computacional, Departamento de Biologia Celular, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil

Abstract

α-Alkylidene δ-lactones are novel modulators of QS at the transcriptional level in CV026. Blind docking calculations found the best inhibitor interacting with CViR AIBD by a molecular binding mechanism distinct from classic AHL-based inhibitors.

Funder

Fundação de Apoio à Pesquisa do Distrito Federal

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01975F

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