A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas

Author:

Xu Xiaoying12345,Liu Kang678910,Wang Yue1112139ORCID,Zhang Changchang12345,Shi Menghan12345,Wang Peng12345,Shen Linghong141516179,Xia Jindong1112139,Ye Ling6789ORCID,Shi Xiangyang12345ORCID,Shen Mingwu12345ORCID

Affiliation:

1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials

2. International Joint Laboratory for Advanced Fiber and Low-dimension Materials

3. College of Chemistry

4. Chemical Engineering and Biotechnology

5. Donghua University

6. School of Chemical Biology and Pharmaceutical Sciences

7. Capital Medical University

8. Beijing 100069

9. People's Republic of China

10. Department of Pharmacy

11. Department of Radiology

12. Shanghai Songjiang District Central Hospital

13. Shanghai 201600

14. Department of Cardiology

15. Shanghai Chest Hospital

16. Shanghai Jiaotong University School of Medicine

17. Shanghai 200030

Abstract

An RGD peptide-targeted low-generation dendrimer nanoprobe can cross the blood-brain barrier for dual-modal MR/CT imaging of an orthotopic brain glioma.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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