Selective in vitro anti-cancer activity of non-alkylating minor groove binders-Reference-Cited by-同舟云学术

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Published:2019 Issue:9 Volume:10 Page:1620-1634
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Nichol Ryan J. O.¹²³⁴⁵,Khalaf Abedawn I.⁶⁷⁸⁹⁵^ORCID,Sooda Kartheek¹⁰²³⁴⁵,Hussain Omar¹⁰²³⁴⁵,Griffiths Hollie B. S.¹²³⁴⁵,Phillips Roger¹⁰²³⁴⁵^ORCID,Javid Farideh A.¹⁰²³⁴⁵^ORCID,Suckling Colin J.⁶⁷⁸⁹⁵,Allison Simon J.¹²³⁴⁵^ORCID,Scott Fraser J.⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Department of Biological and Geographical Sciences

2. School of Applied Sciences

3. University of Huddersfield

4. Huddersfield

5. UK

6. Department of Pure and Applied Chemistry

7. WestCHEM

8. University of Strathclyde

9. Glasgow

10. Department of Pharmacy

Abstract

We describe the synthesis and evaluation of Strathclyde Minor Groove Binders (S-MGBs) as selective anti-cancer agents which act through a non-alkylating mechanism.

Funder

Rosetrees Trust

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00268E

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