A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

Author:

Lin Chao1234,Du Hong-Jin1234,Zhao Hui1234,Yan Ding-Fei1234,Liu Nai-Xin1234,Sun Hongbin1234,Wen Xiaoan1234,Xu Qing-Long1234ORCID

Affiliation:

1. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines

2. China Pharmaceutical University

3. Nanjing 210009

4. China

Abstract

A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to afford polycyclic indolines in good yields.

Funder

Natural Science Foundation of Jiangsu Province

Changjiang Scholar Program of Chinese Ministry of Education

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference56 articles.

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2. E. Fattorusso and O. T.Scafati, Modern Alkaloids, Wiley-VCH, Weinheim, 2008

3. Catalytic Asymmetric Dearomatization Reactions

4. Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions

5. Synthesis of 3-arylated indolines from dearomatization of indoles

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