Chemoenzymatic total synthesis of rotigotine <i>via</i> IRED-catalyzed reductive amination-Reference-Cited by-同舟云学术

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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

Published:2024 Issue:19 Volume:22 Page:3843-3847
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tang Dongyu¹²,Ma Yaqing²,Bao Jinping²,Gao Shushan²³,Man Shuli¹,Cui Chengsen²³^ORCID

Affiliation:

1. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China

Abstract

An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.

Funder

National Key Research and Development Program of China

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00072B

Reference40 articles.

1. Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

2. A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors

3. Synthesis and Biological Evaluation of Novel Compounds within a Class of 3-Aminochroman Derivatives with Dual 5-HT1A Receptor and Serotonin Transporter Affinity

4. Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial

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