Synthetic access to diverse thiazetidines via a one-pot microwave assisted telescopic approach and their interaction with biomolecules

Author:

Rao Ramdas Nishanth1,Das Soumyadip1,Jacob Kezia1,Alam Mohammed Mujahid2,Balamurali M. M.3ORCID,Chanda Kaushik14ORCID

Affiliation:

1. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, India

2. Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia

3. Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu, 600027, India

4. Department of Chemistry, Rabindranath Tagore University, Hojai 782435, Assam, India

Abstract

Computationally revealed mechanistic pathway of one-pot telescopically approached thiazetidine synthesis revealed the formation of a single product. The position of alkyl substitution plays significant role to enhance biomolecular interactions.

Funder

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

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