Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines-Reference-Cited by-同舟云学术

Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines

Published:2018 Issue:14 Volume:5 Page:2171-2178
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Olivon F.¹²³⁴⁵^ORCID,Apel C.¹²³⁴⁵^ORCID,Retailleau P.¹²³⁴⁵^ORCID,Allard P. M.⁶⁷⁸⁹¹⁰^ORCID,Wolfender J. L.⁶⁷⁸⁹¹⁰^ORCID,Touboul D.¹²³⁴⁵^ORCID,Roussi F.¹²³⁴⁵^ORCID,Litaudon M.¹²³⁴⁵^ORCID,Desrat S.¹²³⁴⁵^ORCID

Affiliation:

1. Institut de Chimie des Substances Naturelles

2. CNRS-ICSN

3. UPR 2301

4. Université Paris-Saclay

5. Gif-sur-Yvette

6. School of Pharmaceutical Sciences

7. University of Geneva

8. University of Lausanne

9. 1211 Geneva 11

10. Switzerland

Abstract

Four unprecedented chlorinated monoterpenyl quinolones have been isolated using a molecular networking based prioritisation strategy. The bio-inspired total synthesis of chloroaustralasine A involving a chloroperoxydase-mediated hydroxychlorination is described.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00429C

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