Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone–ferrocene hybrids as novel RalA inhibitors-Reference-Cited by-同舟云学术

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Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone–ferrocene hybrids as novel RalA inhibitors

Published:2018 Issue:14 Volume:5 Page:2229-2233
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Yuehua¹²³⁴⁵,Wang Chunting¹²³⁴⁵,Huang Wei⁶⁷⁸⁵^ORCID,Haruehanroengra Phensinee⁹¹⁰¹¹¹²¹³,Peng Cheng⁶⁷⁸⁵^ORCID,Sheng Jia⁹¹⁰¹¹¹²¹³,Han Bo⁶⁷⁸⁵⁹^ORCID,He Gu¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University

4. Chengdu 610041

5. China

6. School of Pharmacy

7. Chengdu University of Traditional Chinese Medicine

8. Chengdu 611137

9. Department of Chemistry and The RNA Institute

10. University at Albany

11. State University of New York

12. Albany

13. USA

Abstract

Asymmetric construction of chiral spirocyclic pyrazolone–ferrocene hybrids has been developed. The lead compound displayed potent RalA inhibition.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00422F

Reference50 articles.

1. A. J. L. Pombeiro , Advances in Organometallic Chemistry and Catalysis , Wiley , Hoboken , 2014

2. New Principles in Medicinal Organometallic Chemistry

3. Bioorganometallic chemistry—from teaching paradigms to medicinal applications

4. Organometallic Anticancer Compounds

5. Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

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