Determination of protonation states of iminosugar–enzyme complexes using photoinduced electron transfer-Reference-Cited by-同舟云学术

Determination of protonation states of iminosugar–enzyme complexes using photoinduced electron transfer

Published:2017 Issue:11 Volume:8 Page:7383-7393
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Wang Bo¹²³⁴^ORCID,Olsen Jacob Ingemar¹²³⁴^ORCID,Laursen Bo W.¹²³⁴^ORCID,Navarro Poulsen Jens Christian¹²³⁴^ORCID,Bols Mikael¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Copenhagen

3. DK-2100 Copenhagen Ø

4. Denmark

Abstract

N-alkylated analogues of 1-deoxynojirimycin inhibit β-glucosidase from white rot fungus. The amino group in the β-glucosidase–iminosugar complex is unprotonated when bound, while an active site carboxylate is protonated.

Funder

FNU

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC01540B

Reference39 articles.

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3. Structural Basis of α‐Fucosidase Inhibition by Iminocyclitols with K i Values in the Micro‐ to Picomolar Range

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