An enzyme-activatable and cell-permeable MnIII-porphyrin as a highly efficient T1 MRI contrast agent for cell labeling-Reference-Cited by-同舟云学术

An enzyme-activatable and cell-permeable MnIII-porphyrin as a highly efficient T1 MRI contrast agent for cell labeling

Published:2016 Issue:7 Volume:7 Page:4308-4317
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Haedicke Inga E.¹²³⁴⁵,Li Tan⁶⁷³⁴,Zhu Yong Le K.¹²³⁴⁵,Martinez Francisco⁸⁹¹⁰⁴¹¹,Hamilton Amanda M.⁸⁹¹⁰⁴¹¹,Murrell Donna H.⁸⁹¹⁰⁴¹¹,Nofiele Joris T.¹²¹³¹⁴³¹⁵,Cheng Hai-Ling M.¹²¹³¹⁴³¹⁵,Scholl Timothy J.⁸⁹¹⁰⁴¹¹,Foster Paula J.⁸⁹¹⁰⁴¹¹,Zhang Xiao-an¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. University of Toronto

3. Toronto

4. Canada

5. Department of Physical and Environmental Sciences

6. Department of Biological Sciences

7. University of Toronto Scarborough

8. Imaging Research Laboratories

9. Robarts Research Institute

10. London

11. Department of Medical Biophysics

12. Physiology & Experimental Medicine

13. The Research Institute

14. Hospital for Sick Children

15. Canada M5G 1X8

Abstract

MnAMP, a cell-trappable pro-contrast agent gets enzymatically activated and accumulated intracellularly to provide a strong MRI signal for cell labeling.

Funder

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

University of Toronto Scarborough

Heart and Stroke Foundation of Canada

Sick Kids Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04252F