Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view-Reference-Cited by-同舟云学术

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

Published:2016 Issue:18 Volume:45 Page:4929-4952
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Lu Shaoyong¹²³⁴⁵,Jang Hyunbum⁶⁷⁸⁹¹⁰,Gu Shuo¹²³⁴⁵,Zhang Jian¹²³⁴⁵,Nussinov Ruth⁶⁷⁸⁹¹⁰

Affiliation:

1. Department of Pathophysiology

2. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education

3. Shanghai Children's Medical Center

4. Shanghai Jiao Tong University

5. School of Medicine

6. Cancer and Inflammation Program

7. Leidos Biomedical Research, Inc.

8. Frederick National Laboratory

9. National Cancer Institute

10. Frederick

Abstract

In this review we overview current advances in Ras structural knowledge and the signaling pathways that can be co-targeted along with Ras to mitigate drug resistance.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CS/C5CS00911A

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