Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor-Reference-Cited by-同舟云学术

Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

Published:2018 Issue:23 Volume:8 Page:12614-12618
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Du Li-Hua¹²³⁴^ORCID,Shen Jia-Hong¹²³⁴^ORCID,Dong Zhen¹²³⁴,Zhou Na-Ni¹²³⁴^ORCID,Cheng Bing-Zhuo¹²³⁴,Ou Zhi-Min¹²³⁴,Luo Xi-Ping⁵⁶³⁴

Affiliation:

1. College of Pharmaceutical Science

2. Zhejiang University of Technology

3. Hangzhou

4. China

5. Department of Environmental Science and Technology

6. Zhejiang A&F University

Abstract

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA01030G

Reference38 articles.

1. Liquid phase oxidation chemistry in continuous-flow microreactors

2. The past, present and potential for microfluidic reactor technology in chemical synthesis

3. Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

4. Taming hazardous chemistry by continuous flow technology

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