Towards skin-on-a-chip for screening the dermal absorption of cosmetics

Author:

Govey-Scotland Jessica12,Johnstone Liam3,Myant Connor1,Friddin Mark S.124ORCID

Affiliation:

1. Dyson School of Design Engineering, Imperial College London, Exhibition Road, South Kensington, SW7 2AZ, London, UK

2. Institute for Molecular Sciences and Engineering, Imperial College London, Exhibition Road, South Kensington, SW7 2AZ, London, UK

3. Office for Product Safety and Standards, 1 Victoria Street, SW1H 0ET, London, UK

4. fabriCELL, Imperial College London and Kings College London, London, UK

Abstract

We explore how artificial cells and tissues could be designed, manufactured on-chip and 3D printed for use in place of ex vivo animal tissues when screening cosmetics for dermal absorption.

Funder

Imperial College London

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference87 articles.

1. The Product Safety and Metrology etc. (Amendment etc. ) (EU Exit) Regulations 2019 , Statute Law Database

2. https://webarchive.nationalarchives.gov.uk/eu-exit/ , https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02009R1223-20201203

3. A State-of-the-Art Review on the Alternatives to Animal Testing for the Safety Assessment of Cosmetics

4. Guideline No. 497: Defined Approaches on Skin Sensitisation , OECD , 2021

5. Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation , OECD , 2022

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