Progress towards the broad use of non-peptide synthetic macrocycles in drug discovery-Reference-Cited by-同舟云学术

Progress towards the broad use of non-peptide synthetic macrocycles in drug discovery

Published:2017 Issue:37 Volume:15 Page:7729-7735
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Whitty Adrian¹²³⁴^ORCID,Viarengo Lauren A.¹²³⁴^ORCID,Zhong Mengqi¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Boston University

3. Boston

4. USA

Abstract

The broad use of non-peptide synthetic macrocycles in drug discovery is benefitting from recent advances in our understanding of what molecular properties define a useful macrocyclic screening hit.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00056A

Reference47 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

2. The exploration of macrocycles for drug discovery — an underexploited structural class

3. Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

4. How proteins bind macrocycles

5. Multiple Multicomponent Macrocyclizations (MiBs): A Strategic Development Toward Macrocycle Diversity

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, Synthesis, Characterization, Enzyme Inhibition, Molecular Docking, and Pharmacological Evaluation of New Chalcone‐Sulfonate Derivatives Bearing Thiophene;ChemistrySelect;2024-04-09

2. Synthesis and Functionalization of Azetidine‐Containing Small Macrocyclic Peptides;Chemistry – A European Journal;2024-04-09

3. Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides;Nature Communications;2024-03-21

4. Novel Mannich bases derived from 1,2,4-triazoles: Design, synthesis, characterization, and glutathione S-transferase inhibition properties investigations;Journal of Molecular Structure;2023-12

5. In Vitro and In Silico Evaluation of Amylase, Tyrosinase, and Pancreatic Lipase Inhibitions of Novel Benzothiazole‐Sulfonate Derivatives;ChemistrySelect;2023-11-08