Clickable styryl dyes for fluorescence labeling of pyrrolidinyl PNA probes for the detection of base mutations in DNA

Author:

Ditmangklo Boonsong12345,Taechalertpaisarn Jaru12345ORCID,Siriwong Khatcharin67389,Vilaivan Tirayut12345ORCID

Affiliation:

1. Organic Synthesis Research Unit

2. Department of Chemistry

3. Faculty of Science

4. Chulalongkorn University

5. Bangkok 10330

6. Materials Chemistry Research Center

7. Department of Chemistry and Center of Excellence for Innovation in Chemistry

8. Khon Kaen University

9. Khon Kaen 40002

Abstract

Styryl dyes clicked to the backbone of pyrrolidinyl PNA probes show significant fluorescence enhancements in response to structural defects in PNA·DNA duplexes.

Funder

Thailand Research Fund

Chulalongkorn University

National Science and Technology Development Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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