The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor-Reference-Cited by-同舟云学术

The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor

Published:2016 Issue:16 Volume:52 Page:3340-3343
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Na¹²³⁴⁵,Zhu Shiping¹²³⁴⁵,Zhang Xianghua⁶⁷³⁸⁵,Yin Xunkui¹²³⁴⁵,Dong Guoqiang¹²³⁴⁵,Yao Jianzhong¹²³⁴⁵,Miao Zhenyuan¹²³⁴⁵,Zhang Wannian¹²³⁴⁵,Zhang Xiaonan⁹¹⁰¹¹⁵,Sheng Chunquan¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Second Military Medical University

4. Shanghai 200433

5. China

6. The First Department of Hepatic Surgery

7. Eastern Hepatobiliary Hospital

8. Shanghai 200438

9. Shanghai Public Health Clinical Center

10. Fudan University

11. Shanghai 201508

Abstract

A novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening. Further target characterization and structural optimization led to the identification of potent anti-HCV molecules targeting NS5A.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC10594C

Reference22 articles.

1. Evolving epidemiology of hepatitis C virus

2. Unravelling hepatitis C virus replication from genome to function

3. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

4. Promising Targets for Anti-Hepatitis C Virus Agents

5. Current and Future Therapies for Hepatitis C Virus Infection

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