An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury-Reference-Cited by-同舟云学术

An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury

Published:2018 Issue:12 Volume:6 Page:3397-3409
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Hu Jing-Bo¹²³⁴⁵,Liu Di¹²³⁴⁵,Qi Jing¹²³⁴⁵,Lu Kong-jun¹²³⁴⁵,Jin Fei-yang¹²³⁴⁵,Ying Xiao-Ying¹²³⁴⁵,You Jian¹²³⁴⁵,Du Yong-Zhong¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Pharmaceutics

2. College of Pharmaceutical Sciences

3. Zhejiang University

4. Hangzhou 310058

5. China

Abstract

Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/BM/C8BM00813B

Reference24 articles.

1. Sepsis and Acute Kidney Injury

2. Acute kidney injury: changing lexicography, definitions, and epidemiology