Citrus peel flavonoid nobiletin alleviates lipopolysaccharide-induced inflammation by activating IL-6/STAT3/FOXO3a-mediated autophagy-Reference-Cited by-同舟云学术

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Citrus peel flavonoid nobiletin alleviates lipopolysaccharide-induced inflammation by activating IL-6/STAT3/FOXO3a-mediated autophagy

Published:2021 Issue:3 Volume:12 Page:1305-1317
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Rong Xue¹²³⁴,Xu Jie¹²³⁴,Jiang Yang¹²³⁴^ORCID,Li Feng¹²³⁴,Chen Yilun¹²³⁴,Dou Q. Ping⁵⁶⁷⁸⁹,Li Dapeng¹²³⁴^ORCID

Affiliation:

1. Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes

2. College of Food Science and Engineering

3. Shandong Agricultural University

4. China

5. Barbara Ann Karmanos Cancer Institute and Departments of Oncology

6. Pharmacology and Pathology

7. Wayne State University School of Medicine

8. Wayne State University

9. Detroit

Abstract

Nobiletin, a polymethoxyflavone widely present in the peel of citrus fruits, has significant anti-inflammatory activity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02141E

Reference69 articles.

1. Peel oils from three Citrus species: volatile constituents, antioxidant activities and related contributions of individual components

2. Filtration-compression step as downstream process for flavonoids extraction from citrus peels: Performances and flavonoids dispersion state in the filtrate

3. Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of Citrus unshiu

4. Rheological characterization of a pectin extracted from ponkan (Citrus reticulata blanco cv. ponkan) peel

5. Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis

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1. Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice;Food Bioscience;2024-12

2. Nobiletin Regulates Polyinosinic-polycytidylic Acid-induced Inflammation in Macrophages Partially via the PPAR-γ Signaling Pathway;Current Pharmaceutical Design;2024-10

3. Human Amniotic Epithelial Stem Cells Activate Autophagy via the IL-6/STAT3/FOXO3a Pathway to Facilitate Liver Regeneration Following Hepatectomy;Current Stem Cell Research & Therapy;2024-07-04

4. Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect;Nutrients;2024-06-29

5. Recent advances in the therapeutic potential of nobiletin against respiratory diseases;Phytomedicine;2024-06

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