Acceptor-mediated regioselective enzyme catalyzed sialylation: chemoenzymatic synthesis of GAA-7 ganglioside glycan-Reference-Cited by-同舟云学术

Acceptor-mediated regioselective enzyme catalyzed sialylation: chemoenzymatic synthesis of GAA-7 ganglioside glycan

Published:2021 Issue:28 Volume:57 Page:3468-3471
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Tseng Hsin-Kai¹²³⁴⁵,Su Yung-Yu¹²³⁴⁵,Chang Ting-Wei¹²³⁴⁵,Liu Hsin-Chien¹²³⁴⁵,Li Pei-Jhen¹²³⁴⁵,Chiang Pei-Yun¹²³⁴⁵,Lin Chun-Cheng¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. National Tsing Hua University

3. 101 Section 2

4. Kuang Fu Road

5. Hsinchu 30013

Abstract

The glycan of GAA-7 was facilely synthesized by enzymatic glycosylation through changing the nonreducing acceptor into GalNH₂ or GalAz to successfully switch the regioselectivity of PmST1.

Funder

National Tsing Hua University

Academia Sinica

Ministry of Science and Technology, Taiwan

Ministry of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC00653C

Reference37 articles.

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3. The Pathogenic Role of Ganglioside Metabolism in Alzheimer’s Disease-Cholinergic Neuron-Specific Gangliosides and Neurogenesis

4. GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer’s Disease

5. GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration

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