Novel vinyl-modified RGD conjugated silica nanoparticles based on photo click chemistry for in vivo prostate cancer targeted fluorescence imaging

Author:

Li Hanrui12345,Li Ke67894,Zeng Qi12345,Zeng Yun12345,Chen Dan12345,Pang Liaojun12345,Chen Xueli12345,Zhan Yonghua12345ORCID

Affiliation:

1. Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education

2. School of Life Science and Technology

3. Xidian University

4. Xi'an

5. China

6. Shaanxi Key Laboratory of Ischemic Cardiovascular Disease

7. Shaanxi Key Laboratory of Brain Disorders

8. Institute of Basic and Translational Medicine

9. Xi'an Medical University

Abstract

Photo click chemistry has been used to prepare RGD conjugated silica nanoprobe (SiO2@T1-RGDk NPs) that exhibits excellent tumor targeting ability and negligible toxicity which enables them to be used for the diagnosis and treatment of cancer.

Funder

National Natural Science Foundation of China

Fok Ying Tung Education Foundation

Fundamental Research Funds for the Central Universities

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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