Anticancer and antitrypanosomal activities of trinuclear ruthenium compounds with orthometalated phenazine ligands-Reference-Cited by-同舟云学术

Anticancer and antitrypanosomal activities of trinuclear ruthenium compounds with orthometalated phenazine ligands

Published:2020 Issue:45 Volume:49 Page:16440-16452
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

da Silva Camila Fontes Neves¹²³⁴⁵,Chrispim Pedro Branco Hauch¹²³⁴⁵^ORCID,Possato Bruna⁶⁵⁷⁸,Portapilla Gisele Bulhões⁶⁵⁷⁸^ORCID,Rohrabaugh Thomas N.⁹¹⁰¹¹¹²,Ramos Loyanne Carla Barbosa⁶⁵⁷⁸,Santana da Silva Roberto⁶⁵⁷⁸^ORCID,de Albuquerque Sérgio⁶⁵⁷⁸,Turro Claudia⁹¹⁰¹¹¹²,Nikolaou Sofia¹²³⁴⁵^ORCID

Affiliation:

1. LABIQSC2 (Laboratório de Atividade Biológica e Química Supramolecular de Compostos de Coordenação)

2. Departamento de Química

3. Faculdade de Filosofia

4. Ciências e Letras de Ribeirão Preto

5. Universidade de São Paulo

6. Faculdade de Ciências Farmacêuticas de Ribeirão Preto

7. 14040-903 Ribeirão Preto

8. Brazil

9. Department of Chemistry and Biochemistry

10. The Ohio State University

11. Columbus

12. USA

Abstract

Four metalo-intercalators ([Ru₃(μ₃-O)(μ₂-OAc)₅(L)(py)₂]PF₆, L = phenazines) present high DNA intercalation constants and high HSA affinity. They are active against melanoma cancer and T. Cruzi parasite.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01035A

Reference101 articles.

1. Epidemiology of American Trypanosomiasis (Chagas Disease)