Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium-Reference-Cited by-同舟云学术

Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium

Published:2022 Issue:13 Volume:12 Page:7594-7604
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kundu Nikita¹,Sharma Taniya¹,Kaur Sarvpreet¹,Singh Mamta²,Kumar Vinit²,Sharma Uttam³,Jain Aklank³,Shankaraswamy Jadala⁴,Miyoshi Daisuke⁵^ORCID,Saxena Sarika¹^ORCID

Affiliation:

1. Amity Institute of Biotechnology, Amity University Uttar Pradesh, Structural Biology Lab, Sector-125, Expressway Highway, Noida 201313, India

2. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Uttar Pradesh, Noida 201313, India

3. Department of Animal Sciences, Central University of Punjab, Bathinda, India

4. Department of Fruit Science, College of Horticulture, Mojerla, Sri Konda Laxman Telangana State Horticultural University, 509382, Telangana, India

5. Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Abstract

We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE) III1 region of the c-Myc promoter and for the first time performed its interaction studies with a designed peptide (QW10).

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA00535B

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2. Highly prevalent putative quadruplex sequence motifs in human DNA

3. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription