Exploring the inhibitory mechanism of piceatannol on α-glucosidase relevant to diabetes mellitus
Author:
Affiliation:
1. School of Life and Pharmaceutical Sciences
2. Dalian University of Technology
3. Panjin 124221
4. China
5. Department of Occupational and Environmental Health
6. Dalian Medical University
7. Dalian 116044
Abstract
The non-competitive inhibition of piceatannol on α-glucosidase. A combination of dynamic and static process with one binding site. The involvement of hydrophobic interactions and hydrogen bonding. Dietary recommendations for diabetes or potential antidiabetic drug.
Funder
National Basic Research Program of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA09028B
Reference43 articles.
1. World Health Organization , avaiable from: https://www.who.int/diabetes/global-report , 2016 , accessed February 11, 2019
2. α-Glucosidase inhibitory effect of resveratrol and piceatannol
3. Long-Term Complications of Diabetes Mellitus
4. Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
5. An Extended Minimal Physiologically Based Pharmacokinetic Model: Evaluation of Type II Diabetes Mellitus and Diabetic Nephropathy on Human IgG Pharmacokinetics in Rats
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