hIAPP forms toxic oligomers in plasma-Reference-Cited by-同舟云学术

hIAPP forms toxic oligomers in plasma

Published:2018 Issue:43 Volume:54 Page:5426-5429
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Rodriguez Camargo Diana C.¹²³⁴⁵,Garg Divita⁶²⁷⁴⁸,Buday Katalin⁸⁹¹⁰⁴,Franko Andras⁸¹¹¹⁰⁴¹²^ORCID,Rodriguez Camargo Andres¹³¹⁴¹⁵¹⁶,Schmidt Fabian⁶²⁷⁴,Cox Sarah J.⁵¹⁷¹⁸¹⁹²⁰,Suladze Saba⁸²¹¹⁰⁴,Haslbeck Martin⁶²⁷⁴,Mideksa Yonatan G.¹²³⁴⁶,Gemmecker Gerd⁶²⁷⁴,Aichler Michaela⁸²²¹⁰⁴,Mettenleiter Gabriele⁸²²¹⁰⁴,Schulz Michael⁸¹¹¹⁰⁴¹²,Walch Axel Karl⁸²²¹⁰⁴,Hrabě de Angelis Martin⁸¹¹¹⁰⁴¹²,Feige Matthias J.¹²³⁴⁶,Sierra Cesar A.¹³¹⁴¹⁵¹⁶,Conrad Marcus⁸⁹¹⁰⁴,Tripsianes Konstantinos²³²⁴²⁵²⁶,Ramamoorthy Ayyalusamy¹²³⁴⁵^ORCID,Reif Bernd¹²³⁴⁶^ORCID

Affiliation:

1. Institute for Advanced Study

2. Technische Universität München

3. 85748 Garching

4. Germany

5. Program in Biophysics

6. Munich Center for Integrated Protein Science (CIPS-M) at Department of Chemistry

7. 85747 Garching

8. Helmholtz Zentrum München

9. Institute of Developmental Genetics (IDG)

10. 85764 Neuherberg

11. Institute of Experimental Genetics (IEG)

12. German Center for Diabetes Research (DZD e. V.)

13. Universidad Nacional de Colombia

14. Departament of Chemistry

15. Carrera 30 # 45-03 (Ciudad Universitaria)

16. Colombia

17. Department of Chemistry

18. University of Michigan

19. Ann Arbor

20. USA

21. Institute of Structural Biology (STB)

22. Research Unit Analytical Pathology (AAP)

23. Central European Institute of Technology (CEITEC)

24. Masaryk University

25. 62500 Brno

26. Czech Republic

Abstract

Glucose and lipid containing particles such as LDL interact with hIAPP, resulting in the formation of hIAPP oligomeric structures that yield an intrinsic fluorescence and toxicity in cellular assays.

Funder

Seventh Framework Programme

Deutsche Forschungsgemeinschaft

Helmholtz-Gemeinschaft

National Institutes of Health

Deutscher Akademischer Austauschdienst

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC03097A

Reference41 articles.

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2. Demography: To the limit

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4. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

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