Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions

Author:

Barosi Anna12345,Dunkel Petra12345ORCID,Guénin Erwann67895ORCID,Lalatonne Yoann67895ORCID,Zeitoun Philippe101112135,Fitton Isabelle14155ORCID,Journé Clément67895,Bravin Alberto1617185ORCID,Maruani Antoine19202122,Dhimane Hamid12345ORCID,Motte Laurence67895ORCID,Dalko Peter I.12345ORCID

Affiliation:

1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

2. Université Paris Descartes

3. UMR 8601

4. 75210 Paris

5. France

6. Laboratory for Vascular Translational Sciences (LVTS)

7. INSERM

8. U1148

9. Université Paris 13

10. Laboratoire d’Optique Appliquée

11. UMR 7639 ENSTA-ParisTech, CNRS

12. Institut Polytechnique de Paris

13. 91120 Palaiseau

14. Service de Radiologie Hôpital Européen Georges Pompidou

15. Paris

16. ESRF

17. ID17 Beamline

18. 38043 Grenoble

19. Department of Chemistry

20. University College London

21. London

22. UK

Abstract

The nano-sized delivery system allowed releasing complex organic ligands by X-ray irradiation. Marked difference was observed in the release efficiency by using conventional Cs-137 vs. pulsed sources.

Funder

Centre National de la Recherche Scientifique

Université Paris Descartes

Université Paris Diderot

Université Paris 13

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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