4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules-Reference-Cited by-同舟云学术

4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules

Published:2020 Issue:8 Volume:11 Page:919-922
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Haskali Mohammad B.¹²³⁴⁵^ORCID,Farnsworth Ashleigh L.⁶⁷⁴⁸⁷^ORCID,Roselt Peter D.¹²³⁴^ORCID,Hutton Craig A.⁶⁷⁴⁸⁷^ORCID

Affiliation:

1. The Centre for Molecular Imaging and Translational Research Laboratory

2. The Peter MacCallum Cancer Centre

3. Melbourne

4. Australia

5. Sir Peter MacCallum Department of Oncology

6. School of Chemistry

7. The University of Melbourne

8. Bio21 Molecular Science and Biotechnology Institute

Abstract

A comparative study of PNP- and TFP-activated esters of radiolabelled prosthetic groups demonstrates the superiority of PNP esters in terms of stability and yields for use in one-step radiolabelling of small molecules and peptides.

Funder

Peter MacCallum Cancer Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00140F

Reference21 articles.

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