Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells-Reference-Cited by-同舟云学术

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells

Published:2018 Issue:11 Volume:9 Page:1831-1842
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Nagiec Marek M.¹²³⁴^ORCID,Duvall Jeremy R.¹²³⁴,Skepner Adam P.¹²³⁴,Howe Eleanor A.¹²³⁴,Bastien Jessica¹²³⁴,Comer Eamon¹²³⁴,Marie Jean-Charles¹²³⁴,Johnston Stephen E.¹²³⁴^ORCID,Negri Joseph¹²³⁴,Eichhorn Michelle¹²³⁴,Vantourout Julien¹²³⁴,Clish Clary⁵²³⁴,Musunuru Kiran⁶⁷³⁴,Foley Michael¹²³⁴,Perez Jose R.¹²³⁴,Palmer Michelle A. J.¹²³⁴

Affiliation:

1. Therapeutics Platform

2. Broad Institute of MIT and Harvard

3. Cambridge

4. USA

5. Metabolite Profiling Platform

6. Department of Stem Cell and Regenerative Biology

7. Harvard University

Abstract

Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease.

Funder

Broad Institute

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00297E

Reference23 articles.

1. Biological, clinical and population relevance of 95 loci for blood lipids

2. TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions