An enzymatic acetal/hemiacetal conversion for the physiological temperature activation of the alkoxyamine C–ON bond homolysis-Reference-Cited by-同舟云学术

An enzymatic acetal/hemiacetal conversion for the physiological temperature activation of the alkoxyamine C–ON bond homolysis

Published:2020 Issue:19 Volume:7 Page:2916-2924
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Albalat Muriel¹²³,Audran Gérard¹²⁴³,Holzritter Maxence¹²⁴³,Marque Sylvain R. A.¹²⁴³^ORCID,Mellet Philippe⁵⁶³⁷⁶^ORCID,Vanthuyne Nicolas¹²³,Voisin Pierre⁷⁶³

Affiliation:

1. Aix-Marseille Univ

2. CNRS

3. France

4. 13397 Marseille Cedex 20

5. INSERM

6. 33076 Bordeaux Cedex

7. Centre de Résonance Magnétique des Systèmes Biologiques

Abstract

Enzymatic trigger. Upon enzymatic hydrolysis by Subtilisin A, highly stable alkoxyamines are transformed into highly labile alkoxyamines able to homolyze spontaneously in less than 500 seconds, at 37 °C.

Funder

Aix-Marseille Université

Centre National de la Recherche Scientifique

Université de Bordeaux

Institut National de la Santé et de la Recherche Médicale

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00559B