The influence of surface modified poly(l-lactic acid) films on the differentiation of human monocytes into macrophages

Author:

Correia Clara R.12345,Gaifem Joana678910,Oliveira Mariana B.12345,Silvestre Ricardo678910,Mano João F.12345ORCID

Affiliation:

1. 3B's Research Group – Biomaterials

2. Biodegradables and Biomimetics

3. University of Minho

4. Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine

5. Guimarães

6. ICVS/3B's – PT Government Associate Laboratory

7. Braga/Guimarães

8. Portugal

9. Life and Health Sciences Research Institute (ICVS)

10. School of Health Sciences

Abstract

The interaction of human monocytes with different surface modified poly(l-lactic acid) films was evaluated. All surface modified films disrupted the balance of macrophage polarization towards a favorable anti-inflammatory profile, particularly after an LPS stimulus.

Funder

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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