Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and lipophilicity-Reference-Cited by-同舟云学术

Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and lipophilicity

Published:2017 Issue:42 Volume:46 Page:14612-14630
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Brown Oliver C.¹²³⁴,Baguña Torres Julia⁵⁶⁷⁴,Holt Katherine B.⁸⁹¹⁰⁴^ORCID,Blower Philip J.⁵⁶⁷⁴^ORCID,Went Michael J.¹²³⁴^ORCID

Affiliation:

1. University of Kent

2. School of Physical Sciences

3. Canterbury CT2 7NH

4. UK

5. King's College London

6. Division of Imaging Sciences and Biomedical Engineering

7. London SE1 7EH

8. University College London

9. Department of Chemistry

10. London

Abstract

A library of copper(ii) bis(thiosemicarbazone) complexes offers independently controlled redox potential and lipophilicity for optimal ⁶⁴Cu PET tracer design.

Funder

Wellcome Trust

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT02008B

Reference59 articles.

1. Molecular imaging of hypoxia in non-small-cell lung cancer

2. Imaging tumour hypoxia with positron emission tomography