A cell permeable bimane-constrained PCNA-interacting peptide-Reference-Cited by-同舟云学术

A cell permeable bimane-constrained PCNA-interacting peptide

Published:2021 Issue:5 Volume:2 Page:1499-1508
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Horsfall Aimee J.¹²³^ORCID,Vandborg Beth A.¹⁴,Kikhtyak Zoya⁵^ORCID,Scanlon Denis B.¹²,Tilley Wayne D.⁵,Hickey Theresa E.⁵,Bruning John B.¹⁴,Abell Andrew D.¹²³^ORCID

Affiliation:

1. Institute of Photonics and Advanced Sensing (IPAS), The University of Adelaide, Adelaide, South Australia, 5005, Australia

2. School of Physical Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia

3. Australian Research Council Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia

4. School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia

5. Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia

Abstract

A small, inherently fluorescent macrocyclic peptide constrained with a bimane-linker is cell permeable, and binds the human sliding clamp protein, PCNA, in a 310-helical conformation with nanomolar affinity.

Funder

National Health and Medical Research Council

National Breast Cancer Foundation

ARC Centre for Nanoscale BioPhotonics

Movember Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00113B

Reference35 articles.

1. PCNA binding proteins

2. Proliferating cell nuclear antigen (PCNA): a dancer with many partners