Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA–coat protein interaction-Reference-Cited by-同舟云学术

Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA–coat protein interaction

Published:2023 Issue:12 Volume:8 Page:1665-1676
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Rodríguez-Espinosa María J.¹²^ORCID,Rodríguez Javier M.²,Castón José R.²³^ORCID,de Pablo Pedro J.¹⁴^ORCID

Affiliation:

1. Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid, Spain

2. Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB-CSIC), 28049 Madrid, Spain

3. Nanobiotechnology Associated Unit CNB-CSIC-IMDEA, Campus Cantoblanco, 28049 Madrid, Spain

4. Instituto de Física de la Materia Condensada (IFIMAC), Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

By using AFM-induced mechanical disassembly we investigate the RNA-cargo retention of individual human picobirnavirus virus-like particles which differ in the N-terminal of their capsid protein, thus changing the RNA-coat protein interaction.

Funder

Ministerio de Ciencia e Innovación

Comunidad de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NH/D3NH00195D

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