2-Amino-6-chloropurine-modified polyamidoamine-mediated p53 gene transfection to achieve anti-tumor efficacy

Author:

Han Haobo12345,Chen Wenqi12345,Yang Jiebing12345,Zhang Jiayuan12345,Li Quanshun12345ORCID,Yang Yan12345

Affiliation:

1. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education

2. School of Life Sciences

3. Jilin University

4. Changchun 130012

5. China

Abstract

The modification of 2-amino-6-chloropurine on polyamidoamine was performed to synthesize a derivative, AP-PAMAM, which was then employed as a carrier for p53 gene delivery to achieve anti-tumor efficacy.

Funder

National Natural Science Foundation of China

Education Department of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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