Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model-Reference-Cited by-同舟云学术

Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model

Published:2021 Issue:22 Volume:9 Page:7547-7564
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yousfan Amal¹,Rubio Noelia²,Al-Ali Mohammad³,Nattouf Abdul Hakim¹,Kafa Houmam³^ORCID

Affiliation:

1. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Syria

2. Department of Chemistry and Materials, Imperial College London, SW7 2AZ, UK

3. Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, Damascus, Syria

Abstract

In this work we describe the preparation and characterization of lecithin–chitosan nanoparticles (L10Ci+), and investigate their ability to deliver the anti-epileptic drug phenytoin (PHT) to mouse brain following intranasal (IN) administration.

Funder

Atomic Energy Commission of Syria

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM01251G

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