Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria-Reference-Cited by-同舟云学术

Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria

Published:2024 Issue:1 Volume:15 Page:283-292
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Chen Ling-Han¹^ORCID,Lin Man-Yi²^ORCID,Lin Hsueh-Chun¹,Yang Fan-Wei³,Liao Hsiao-Wei³^ORCID,Shiau Chung-Wai²,Chiu Hao-Chieh¹⁴^ORCID,Su Jung-Chen³^ORCID

Affiliation:

1. Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan

2. Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan

3. Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan

4. Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10021, Taiwan

Abstract

A tricyclic core derivative, SW33, showed potency against intracellular drug-resistant strains of S. typhimurium and other intracellular pathogens with no toxicity, indicating a broad-spectrum activity against intracellular bacteria.

Funder

National Science and Technology Council

National Taiwan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00418J

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