Discovery of imidazo[1,2-<i>b</i>]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma-Reference-Cited by-同舟云学术

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Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma

Published:2024 Issue:1 Volume:15 Page:178-192
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Akwata Desmond¹,Kempen Allison L.¹^ORCID,Lamptey Jones¹,Dayal Neetu¹,Brauer Nickolas R.¹^ORCID,Sintim Herman O.¹²³^ORCID

Affiliation:

1. Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA

2. Purdue Institute for Drug Discovery, 720 Clinic Drive, West Lafayette, IN 47907, USA

3. Purdue Institute for Cancer Research, 201 S. University St., West Lafayette, IN 47907, USA

Abstract

Increasing activity against TAK1 via “magic” methylation or cyclopropylation.

Funder

Paula and Rodger Riney Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00415E

Reference36 articles.

1. Multiple myeloma: 2020 update on diagnosis, risk‐stratification and management

2. Progress and Paradigms in Multiple Myeloma

3. Induction Therapy Before Transplantation in Multiple Myeloma: New Strategies to Achieve Complete Response

4. An Update of the Management of Multiple Myeloma: The Changing Landscape

5. Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment

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2. Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives;International Journal of Molecular Sciences;2024-05-17

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