SCX-tip-aided LC-MS detection of active ricin<i>via</i>oligonucleotide substrates for depurination kinetics-Reference-Cited by-同舟云学术

SCX-tip-aided LC-MS detection of active ricinviaoligonucleotide substrates for depurination kinetics

Published:2023 Issue:12 Volume:148 Page:2782-2792
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Yang Zhifang¹,Wang Chenyu¹²^ORCID,Xiao Lan¹²,Wang Chuang¹²,Tang Li²,Guo Lei¹^ORCID,Xie Jianwei¹^ORCID

Affiliation:

1. State Key Laboratory of Toxicology and Medical Countermeasures, and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China

2. Key Laboratory of Ethnomedicine Ministry of Education (Minzu University of China), School of Pharmacy, Minzu University of China, China

Abstract

A SCX-tip sample pretreatment way facilitates a LC-TUV-QDa method for the measurement of active ricin and depurination kinetics, which successfully implementsex vitroricin cleavage toward oligo substrates at neutral pH for the first time.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D3AN00217A

Reference45 articles.

1. Ricin: An Ancient Story for a Timeless Plant Toxin

2. The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks

3. Fungal ribotoxins: molecular dissection of a family of natural killers

4. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

5. Structure and stability of variants of the sarcin-ricin loop of 28S rRNA: NMR studies of the prokaryotic SRL and a functional mutant

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