Nontargeted SWATH acquisition mode for metabolites identification of osthole in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Author:
Affiliation:
1. Department of Pharmaceutical Analysis
2. School of Pharmacy
3. Hebei Medical University
4. Shijiazhuang
5. P. R. China
Abstract
Osthole (OST), 7-methoxy-8-isopentenoxycoumarin, is the characteristic constituent found in Cnidium monnieri (L.) Cuss. and possesses excellent pharmacological activities, including anticancer, anti-apoptosis and neuroprotection.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA01221K
Reference35 articles.
1. Chinese Pharmacopoeia Commission , The Pharmacopoeia of the People's Republic of China, Part I , China Medical Science Press , Beijing, China , 2015 , p. 315
2. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS
3. Isolation and Identification of Insecticidal Components from Citrus aurantium Fruit Peel Extract
4. In vitro anticancer activities of osthole against renal cell carcinoma cells
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