Identification of small molecules that are synthetically lethal upon knockout of the RNA ligase Rlig1 in human cells-Reference-Cited by-同舟云学术

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Identification of small molecules that are synthetically lethal upon knockout of the RNA ligase Rlig1 in human cells

Published:2024 Issue:9 Volume:5 Page:833-840
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Stumpf Florian M.¹²,Müller Silke³⁴,Marx Andreas¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany

2. Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany

3. Department of Biology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany

4. Screening Center, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany

Abstract

Six unique compounds were found to be synthetically lethal in combination with Rlig1-KO in HEK293 cells. In addition, several naphthoquinones, which are similar to menadione, were evaluated in this context.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00125G

Reference51 articles.

1. Chemoproteomic discovery of a human RNA ligase

2. HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

3. Diversity and roles of (t)RNA ligases

4. RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates

5. Novel Mechanism of RNA Repair by RtcB via Sequential 2′,3′-Cyclic Phosphodiesterase and 3′-Phosphate/5′-Hydroxyl Ligation Reactions

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