Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step-Reference-Cited by-同舟云学术

Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Published:2022 Issue:15 Volume:9 Page:3998-4002
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xiao Yi¹,Jiang Yangyang¹,Xu Chao²^ORCID,Nakliang Pratanphorn³^ORCID,Yoon Sanghee³,Choi Sun³^ORCID,Guo Yian¹²^ORCID,Ye Tao¹^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen, 518055, China

2. Innovation Center of Marine Biotechnology and Pharmaceuticals, Wuyi University, Jiangmen, 529020, Guangdong, China

3. Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea

Abstract

The total synthesis of the antitumor natural product thioamycolamide A has been accomplished in 19.1% overall yield featuring a diastereoselective sulfa-Michael reaction.

Funder

National Natural Science Foundation of China

Shenzhen Peacock Plan

Science, Technology and Innovation Commission of Shenzhen Municipality

Natural Science Foundation of Guangdong Province

Department of Education of Guangdong Province

National Research Foundation of Korea

Ministry of Health and Welfare

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry