Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure–activity relationship, pharmacokinetics and in vivo evaluation-Reference-Cited by-同舟云学术

Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure–activity relationship, pharmacokinetics and in vivo evaluation

Published:2015 Issue:12 Volume:13 Page:3610-3624
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Munagala Gurunadham¹²³⁴⁵,Yempalla Kushalava Reddy¹²³⁴⁵,Singh Samsher⁵²³⁴⁶,Sharma Sumit¹²³⁴⁵,Kalia Nitin Pal⁶²³⁴,Rajput Vikrant Singh⁵²³⁴⁶,Kumar Sunil⁵²³⁴⁶,Sawant Sanghapal D.¹²³⁴⁵,Khan Inshad Ali⁵²³⁴⁶,Vishwakarma Ram A.¹²³⁴⁵,Singh Parvinder Pal¹²³⁴⁵

Affiliation:

1. Medicinal Chemistry Division

2. CSIR-Indian Institute of Integrative Medicine

3. Jammu 180 001

4. India

5. Academy of Scientific and Innovative Research

6. Clinical Microbiology

Abstract

Promising nitroimidazoloxazole scaffold gives another novel triazolyl-containing 6-nitro-2,3-dihydroimidazooxazole as anti-TB lead.

Funder

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00054H

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4. World Health Organization (WHO) , Treatment of tuberculosis: Guidelines for national programmes, WHO Press, Geneva, Switzerland, 4th edn, 2009

5. Prospects for Clinical Introduction of Nitroimidazole Antibiotics for the Treatment of Tuberculosis

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