Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7-Reference-Cited by-同舟云学术

Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

Published:2015 Issue:19 Volume:13 Page:5418-5423
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Udemba A.¹²³⁴⁵,Smith G.⁶⁷⁵,Nguyen Q.-D.⁸⁹¹⁰¹¹¹²,Kaliszczak M.¹²³⁴⁵,Carroll L.¹²³⁴⁵,Fortt R.¹³¹⁴¹⁵¹⁶⁵,Fuchter M. J.¹⁷³⁴⁵,Aboagye E. O.¹²³⁴⁵

Affiliation:

1. Comprehensive Cancer Imaging Centre

2. Department of Surgery and Cancer

3. Imperial College London

4. London

5. UK

6. Institute of Cancer Research

7. London SW7 3RP

8. Lurie Family Imaging Center

9. Center for Biomedical Imaging in Oncology

10. Dana-Farber Cancer Institute

11. Harvard Medical School

12. Boston

13. Division of Imaging Sciences & Biomedical Engineering

14. King's College London

15. St Thomas’ Hospital

16. London SE1 7EH

17. Department of Chemistry

Abstract

Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management.

Funder

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00058K

Reference22 articles.

1. The Hallmarks of Cancer

2. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

3. New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions

4. 18F-ML-10, a PET Tracer for Apoptosis: First Human Study

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