Molecular mechanisms of the antibacterial activity of polyimide fibers in a skin-wound model with Gram-positive and Gram-negative bacterial infection in vivo

Author:

Yang Xia1ORCID,Ma Wei1,Lin Hua2,Ao Shengxiang1,Liu Haoru1,Zhang Hao1,Tang Wanqi1,Xiao Hongyan1,Wang Fangjie1,Zhu Junyu1,Liu Daoyan1,Lin Shujun3,Zhang Ying4,Zhou Zhongfu5,Chen Changbin6,Liang Huaping1

Affiliation:

1. Department of Wound Infection and Drug, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400042, P. R. China

2. Faculty of Materials and Energy, Southwest University, Chongqing 400715, P. R. China

3. Changchun HiPolyking Co. Ltd., No. 666B, Super Street, Jilin 132000, P. R.China

4. Shanghai Kington Technology Limited, 8 Jinian Road, Shanghai 200433, P. R. China

5. School of Materials Science & Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China

6. The Center for Microbes, Development, and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, P. R. China

Abstract

A novel natural polyimide fiber was identified and displayed significant antibacterial activity against E. coli and MRSA in vitro and in vivo, may act as a promising candidate for antimicrobial material for trauma and surgical applications.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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