Layer-by-layer coated nanoliposomes for oral delivery of insulin-Reference-Cited by-同舟云学术

Layer-by-layer coated nanoliposomes for oral delivery of insulin

Published:2021 Issue:2 Volume:13 Page:776-789
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zhang Yiming¹²³,Xiong Gordon Minru¹²³,Ali Yusuf⁴⁵,Boehm Bernhard O.⁴⁵,Huang Ying Ying¹²³^ORCID,Venkatraman Subbu¹²³

Affiliation:

1. School of Materials Science and Engineering

2. Nanyang Technological University

3. Singapore 639798

4. Lee Kong Chian School of Medicine

5. Singapore 308232

Abstract

Nanosulin – a highly stable multilayer insulin-coated nanoliposome, enhanced insulin permeation across the intestinal epithelium and maintained bioactivity via oral administration in vivo.

Funder

Nanyang Technological University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR06104B

Reference40 articles.

1. Oral Insulin: The Rationale for This Approach and Current Developments

2. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

3. Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

4. Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial

5. Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study

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