Palladium-catalyzed tandem Heck/carbonylation/aminocarbonylation en route to chiral heterocyclic α-ketoamides-Reference-Cited by-同舟云学术

Palladium-catalyzed tandem Heck/carbonylation/aminocarbonylation en route to chiral heterocyclic α-ketoamides

Published:2022 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Hu Huaanzi¹²³,Yu Ting¹³,Cheng Sidi¹³,Li Jing¹³,Gan Chunfang⁴,Luo Shuang¹³⁵^ORCID,Zhu Qiang¹³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China

2. School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, China

3. University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China

4. Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, China

5. Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), 510005 Guangzhou, China

Abstract

An unprecedented tandem carbonylation/aminocarbonylation triggered by palladium-catalyzed enantioselective Heck-type exocyclopalladation delivering chiral heterocyclic α-ketoamides has been developed.

Funder

National Natural Science Foundation of China

Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Natural Science Foundation of Guangdong Province

Bagui Scholars Program of Guangxi Zhuang Autonomous Region

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01680F