A sensitive fluorescence biosensor based on metal ion-mediated DNAzyme activity for amplified detection of acetylcholinesterase-Reference-Cited by-同舟云学术

A sensitive fluorescence biosensor based on metal ion-mediated DNAzyme activity for amplified detection of acetylcholinesterase

Published:2022 Issue:11 Volume:147 Page:2575-2581
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Zhao Xu-Hua¹^ORCID,Dai Xiao-Chun¹,Zhou Ya-Nan¹,Zhang Han-Xiao¹,Cui Xiao-Hua¹,Zhai Xiang¹,Yu Bao-Feng¹,Song Zhi-Ling²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, P. R. China

2. Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

In this paper, we developed an amplified fluorescence biosensor for acetylcholinesterase (AChE) activity detection by taking advantage of the mercury ion-mediated Mgzyme (Mg2+-dependent DNAzyme) activity.

Funder

Natural Science Foundation of Shanxi Province

Ministry of Education of the People's Republic of China

Fund for Shanxi Key Subjects Construction

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D2AN00414C

Reference41 articles.

1. Use of ethopropazine and BW 284C51 as selective inhibitors for cholinesterases from various species

2. Exercise modulates synaptic acetylcholinesterase at neuromuscular junctions

3. Affinity Binding-Guided Fluorescent Nanobiosensor for Acetylcholinesterase Inhibitors via Distance Modulation between the Fluorophore and Metallic Nanoparticle

4. Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

5. Amyloid Fibril Formation by a Synthetic Peptide from a Region of Human Acetylcholinesterase that Is Homologous to the Alzheimer's Amyloid-β Peptide

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