A designer DNA tetrahedron-based molecular beacon for tumor-related microRNA fluorescence imaging in living cells

Author:

Li Shuainan12,Wang Chenguang12,Xu Yi1,Wang Wei3,Zhao Xiaoshuang4,Qian Qiuling12,Mi Xianqiang12456ORCID

Affiliation:

1. Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. Shanghai Pudong New District Zhoupu Hospital (Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital), Shanghai 201318, China

4. Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China

5. CAS Center for Excellence in Superconducting Electronics (CENSE), Shanghai 200050, China

6. Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China

Abstract

A designer nanoprobe of tetrahedral DNA framework (TDF) combined with MB (termed TDFM nanoprobe) for the efficient fluorescence imaging of tumor-related miRNA-214 in living cells.

Funder

Chinese Academy of Sciences

Program of Shanghai Academic Research Leader

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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