Enhanced performance of plasmid DNA polyplexes stabilized by a combination of core hydrophobicity and surface PEGylation
Author:
Affiliation:
1. Department of Chemical and Biomolecular Engineering
2. Vanderbilt University
3. Nashville, USA
4. Department of Biomedical Engineering
5. Department of Pathology
6. Vanderbilt University Medical Center
7. Research Service
Abstract
Nonviral gene therapy has high potential for safely promoting tissue restoration and for treating various genetic diseases.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2014/TB/C4TB00352G
Reference34 articles.
1. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
2. Transgene Expression in the Brain Stem Effected by Intramuscular Injection of Polyethylenimine/DNA Complexes
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