Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria-Reference-Cited by-同舟云学术

Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria

Published:2023 Issue:25 Volume:14 Page:6975-6985
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Abujubara Helal¹,Hintzen Jordi C. J.¹^ORCID,Rahimi Shadi²^ORCID,Mijakovic Ivan²³,Tietze Daniel¹^ORCID,Tietze Alesia A.¹^ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Kemigården 4, 412 96 Göteborg, Sweden

2. Division of Systems & Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, 412 96, Göteborg, Sweden

3. The Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, DK-2800, Kongens Lyngby, Denmark

Abstract

A series of peptidomimetic Sortase A inhibitors is reported. These compounds show inhibition activity of the Sortase A enzyme and efficiently prevent biofilm formation of S. aureus.

Funder

Centre for Antibiotic Resistance Research, University of Gothenburg

Knut och Alice Wallenbergs Stiftelse

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01209C

Reference47 articles.

1. Origins and Evolution of Antibiotic Resistance