Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization-Reference-Cited by-同舟云学术

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Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization

Published:2024 Issue: Volume: Page:
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Alsup Tyler A.¹^ORCID,Li Zining¹^ORCID,McCadden Caitlin A.¹^ORCID,Jagels Annika¹²^ORCID,Łomowska-Keehner Diana P.¹^ORCID,Marshall Erin M.¹²^ORCID,Dong Liao-Bin³^ORCID,Loesgen Sandra¹²^ORCID,Rudolf Jeffrey D.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Florida, Gainesville, Florida, USA

2. Whitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, FL, USA

3. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, China

Abstract

The first key steps in the biosynthesis of the phenalinolactones were investigated using heterologous expression of four core genes that are conserved in this family of bacterial meroterpenoids.

Funder

Division of Chemistry

NIH Office of the Director

Division of Materials Research

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00138A

Reference32 articles.

1. Dictionary of Natural Products, https://dnp.chemnetbase.com (accessed Mar 19, 2024 )

2. Bacterial terpenome

3. Exploration and Mining of the Bacterial Terpenome

4. Genomic basis for natural product biosynthetic diversity in the actinomycetes

5. Terpene synthases are widely distributed in bacteria

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